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Multiorgan Manifestation

PTH Deficiency—Systemic Impact That Puts Multiple
Organs at Risk1-3

A range of symptoms and risks are associated with PTH deficiency and conventional therapy1-3

CENTRAL NERVOUS SYSTEM
  • Seizures
  • Basal ganglia calcifications
  • Parkinsonism or dystonia
CARDIOVASCULAR SYSTEM
  • Cardiac arrhythmias
  • Hypocalcemia-associated dilated cardiomyopathy
  • Vascular calcifications
RENAL SYSTEM
  • Chronic kidney disease*
  • Nephrocalcinosis*
  • Nephrolithiasis*
NEUROMUSCULAR SYSTEM
  • Myopathy
  • Muscle cramps/tetany
  • Paresthesia
NEUROPSYCHIATRIC SYSTEM
  • Cognitive impairment ("brain fog")
  • Symptoms of anxiety and depression
MUSCULOSKELETAL SYSTEM
  • Reduced bone turnover
  • Increased bone density
  • Spondyloarthropathy
CENTRAL NERVOUS SYSTEM
  • Seizures
  • Basal ganglia calcifications
  • Parkinsonism or dystonia
CARDIOVASCULAR SYSTEM
  • Cardiac arrhythmias
  • Hypocalcemia-associated dilated cardiomyopathy
  • Vascular calcifications
NEUROMUSCULAR SYSTEM
  • Myopathy
  • Muscle cramps/tetany
  • Paresthesia
NEUROPSYCHIATRIC SYSTEM
  • Cognitive impairment ("brain fog")
  • Symptoms of anxiety and depression
RENAL SYSTEM
  • Chronic kidney disease*
  • Nephrocalcinosis*
  • Nephrolithiasis*
MUSCULOSKELETAL SYSTEM
  • Reduced bone turnover
  • Increased bone density
  • Spondyloarthropathy
  Adapted by permission from Springer Nature. Nature Reviews Disease Primers. 2017;3:17055. Hypoparathyroidism. Mannstadt M, et al. 2017.
* These manifestations are mostly the result of treatment with pharmacologically high doses of calcium and calcitriol (active vitamin D) rather than of the disease itself.3
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Organ Effects and Risks