Choose an organ to learn more
CENTRAL NERVOUS
SYSTEM
The combination of high phosphorus and high calcium-phosphate product drives the formation of calcium deposits in brain tissue1,10
CARDIOVASCULAR SYSTEM
Elevated calcium phosphate is associated with vascular calcifications, which increases the risk of CV mortality11,12
RENAL SYSTEM
PTH deficiency interferes with calcitriol synthesis, calcium reabsorption, and urinary phosphate excretion, increasing the risk of renal dysfunction3,13,14
MUSCULOSKELETAL SYSTEM
In hypoparathyroidism, hypocalcemia can cause muscle cramps and life-threatening laryngospasm or bronchospasm1,3
SKELETAL SYSTEM
PTH deficiency disrupts key bone remodeling activity, which may increase the risk of bone fractures1,3,15
GASTROINTESTINAL SYSTEM
Without PTH around to promote the synthesis of calcitriol (active vitamin D) in the kidneys, the intestinal absorption of dietary calcium is reduced in hypoparathyroidism3
HYPOPARATHYROIDISM
ONE DISEASE
MULTIPLE RISKS1-3
Hypoparathyroidism is characterized by the absence or deficiency of PTH3
Scroll to take a closer look at the multiorgan impact of hypoparathyroidism1,2,4,5
PTH Deficiency puts multiple organs at risk
See how the symptoms and risks of PTH deficiency can be debilitating1-3
Explore multiorgan impact
SERUM CALCIUM LEVELS DON'T TELL THE WHOLE STORY6,7
Discover the crucial need to address underlying pathophysiology6,7
TAKE A CLOSER LOOK
SOME PATIENTS MAY NOT BE WELL CONTROLLED WITH CONVENTIONAL THERAPY5-8
Identify patients who may still be at risk5,8,9
Know the Signs
